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Dr Jane Nikles is a registered medical practitioner who has conducted research at The University of Queensland in the field of N-of-1 trials for over 20 years. In 2006, she completed a PhD at The University of Queensland; her doctoral work focussed on the use of the N-of-1 trial methodology in clinical practice. She has regular interaction with hospitals and GP practices, both staff and patients. Her research interests lie in advancing the science of N-of-1 trials and exploring the many applications of N-of-1 trials to maximise patient health outcomes. Dr Nikles’ findings have changed practice in regard to more targeted prescribing of chronic pain medications. She was involved in developing the CONSORT Extension for Reporting N-of-1 Trials (CENT), and SCRIBE (The Single-Case Reporting Guideline In BEhavioural Interventions) which are important developments in the field of N-of-1 trials that will improve the reporting of N-of-1 trials. She is currently conducting an international multi-site N-of-1 trial which also compares aggregated N-of-1 trials with parallel arm randomised controlled trials, a world first. This trial, which compares melatonin and placebo for sleep difficulties in children with ADHD on stimulants medication, is actively recruiting participants all over Australia at present. Dr Nikles has published 48 peer-reviewed journal articles in the field and has co-edited a definitive book on N-of-1 trials. Her work has been highly influential, and she is the top author in the N-of-1 trial field. She has published articles in high-ranking journals including European Journal of Clinical Pharmacology, Journal of Clinical Epidemiology, Medical Journal of Australia and British Medical Journal. Her current areas of interest mostly lie within clinical neuroscience – eg pain, sleep – and span pharmacological and non-pharmacological treatments including complementary and alternative medicines. She is very interested in developing new designs for the application of N-of-1 trials to suit these areas of interest and the characteristics of these treatments. Her skills also include trial management and design more broadly.